https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Warburg effect targeting Co(III) cytotoxin chaperone complexes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46316 1, inhibits hexokinase, suggesting that it will be phosphorylated in the cell. A Co(III) complex incorporating this ligand and coumarin-343 hydroximate (C343ha), [Co(C343ha){tpa(CONHPEGglucose)1}]Cl, is shown to exhibit glucose-dependent cellular accumulation in DLD-1 colon cancer cells. Cellular accumulation of [Co(C343ha){tpa(CONHPEGglucose)1}]+ is slower than for the glucose null and glucosamine analogues, and the glucose complex also exhibits a lower ability to inhibit antiproliferative activity. Distributions of cobalt (X-ray fluorescence) and C343ha (visible light fluorescence) in DLD-1 cancer cell spheroids are consistent with uptake of [Co(C343ha){tpa(CONHPEGglucose)1}]+ by rapidly dividing cells, followed by release and efflux of C343ha and trapping of the Co{tpa(CONHPEGglucose)1} moiety. The Co{tpa(CONHPEGglucose)1} moiety is shown to have potential for the caged and targeted delivery of highly toxic anticancer agents.]]> Tue 15 Nov 2022 11:39:06 AEDT ]]> A Warburg effect targeting vector designed to increase the uptake of compounds by cancer cells demonstrates glucose and hypoxia dependent uptake https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36359 Thu 28 Oct 2021 13:03:11 AEDT ]]> Isomers of 1,4,8,11-tetraazacyclotetradecane-6,13-dicarboxylate characterized as cobalt(lll) complexes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:3226 Sat 24 Mar 2018 07:22:15 AEDT ]]> Synthesis and complexation of a chiral sexidentate pendant-arm macropolycyclic polyamino acid https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:3229 Sat 24 Mar 2018 07:22:15 AEDT ]]>